Prohibited substances

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The Prohibited List

The Prohibited List is published by the World Anti-Doping Agency (WADA). It details all substances and methods that are prohibited or banned in sport, and is updated every year on January 1.

A substance or method may be included on the list if it meets any two of the following criteria:

  • it has the potential to enhance sporting performance

  • it presents an actual or potential health risk to the athlete

  • it violates the spirit of sport.

Check if a medication is banned in sport

Search the Prohibited List

2027 Prohibited List updates

WADA has published the updated 2027 Prohibited List alongside the substances on its Monitoring Program for 2027. The 2027 Prohibited List comes into force on 1 January 2027.

Check the 2027 Prohibited List - wada.ama.org

Changes in 2027

S0. Non-Approved Substances

This category includes pharmacological substances which are not addressed by any of the subsequent sections of the List and with no current approval by any governmental regulatory health authority for human therapeutic use. The examples they provide are drugs under pre-clinical or clinical development or discontinued, designer drugs, substances approved only for veterinary use. For the 2027 list, Peptides has been added to the list of examples, for the following reasons

  • Many peptides that are not approved for human use by regulatory authorities may still be prohibited under the WADA Prohibited List.

  • These substances may fall under S0 (Non-Approved Substances) or other categories such as S2 or S4.

  • A peptide does not need to be specifically named on the Prohibited List to be prohibited.

  • Athletes should exercise caution, as these substances may be both prohibited and harmful to health.

  • To improve clarity, examples of peptides have been added to this section.

S4. Hormone and Metabolic Modulators

  • The title of Section S4.2 was updated to reflect current terminology used for this class of substances.

  • Imlunestrant, Seladelpar, SLU-PP-332 and SLU-PP-915 were added to this category.

S5. Diuretics and Masking Agents

  • Eplerenone and finerenone were added as examples within this category.

S8. Cannabinoids

  • Updates were made to reflect current scientific knowledge regarding the Delta-9-tetrahydrocannabinol (Delta9-THC)-like effects of commonly encountered cannabinoids.

  • Cannabidiol (CBD) remains not prohibited.

  • However, cannabidiol products derived from cannabis plants may contain varying concentrations of THC, which remains prohibited.

S9. Glucocorticoids

  • Vaginal administration was added as a permitted route of administration.

P1. Beta-Blockers

  • To align with other international federations, the reference to “all disciplines” was removed from the World Curling Federation (WCBS) entry

Monitoring Program

The following substances were removed as sufficient information has been collected:

  • Codeine

  • dermorphin and its analogues

  • Hydrocodone

  • fentanyl and tramadol Out-of-Competition

GLP-1 receptor agonists

The status of glucagon-like peptide-1 receptor agonists (GLP-1s such as Wegovy and Mounjaro) was extensively reviewed and they will remain permitted in 2027. The expert group noted that this decision may be reconsidered as additional evidence emerges regarding their potential effects on athletes. Given the widespread use of these substances, further research is being encouraged, and WADA has included this topic in its research funding program.

Read more on our blog: 2027 Prohibited List: THC, Peptides and GLP-1s

Check your medications

Even common medications can contain banned substances.

That's why we encourage you to check every medication on Global DRO before using it. Global DRO can tell you if a substance is banned in sport, permitted, or has conditions around its use.

The principle of strict liability means that, as an athlete, you're 100% responsible for anything found in your sample. It's always best to play it safe.

Learn how to check medications using Global DRO

Download the Wallet Guide

Print and fold the Wallet Guide so you always have handy anti-doping information at hand.

Download the 2026 Wallet Guide (PDF 202KB)

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